Cst tmp21
WebApr 27, 2006 · Here we report that TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates γ-secretase cleavage … WebP24 protein family is a group of transmembrane proteins that are major components of COPI and COPII-coated vesicles.The family is also known as EMP24/GP25L/p24 family and TMP21-like proteins.The latter naming was after transmembrane emp24 domain-containing protein 10 that was found in the human brain.It was claimed to block the beta-amyloid …
Cst tmp21
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WebThe recombinant expression vector pcDNA3.1 (+)-TMP21 and specific small interfering RNAs (siRNA) against TMP21 were transfected into a papillary thyroid cancer cell line … WebOct 22, 2024 · Silencing of TMP21 in SH-SY5Y cells also increased the production of cellular reactive oxygen species (ROS). Accordingly, treatment with the ROS scavenger …
WebTMP21 has been shown to be associated with the γ-secretase complex and can specifically regulate γ-cleavage without affecting ϵ-mediated proteolysis. To explore the basis of this activity, TMP21 modulation of γ-secretase … WebSince its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling …
WebBackground. TMP21, a type I transmembrane protein, is a member of the p24 cargo protein family, which is highly enriched in the ER, the Golgi and coat protein (COP) I and II … WebSince its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.
WebThe isolated TMP21 TM peptide but not the homologous p24a domain was able to reduce Aβ production in a dose-dependent fashion. These observations suggest that the TMP21 transmembrane domain promotes …
WebOct 22, 2024 · TMP21, a member of the p24 protein family, plays a critical role in vesicle trafficking [30] and has been identified as an important component of the presenilin-associated γ-secretase complex [21]. The expression level of TMP21 has been reported to be decreased in the brains of patients with AD compared with age-matched controls [22], … can jellyfish survive in freshwaterWebTarget Information. TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin … can jelly give you heartburnWebTMP21 (A-7) is a mouse monoclonal antibody raised against amino acids 41-105 mapping near the N-terminus of TMP21 of human origin. PRODUCT Each vial contains 200 µg … can jennifer connelly really sailWebTMP21 is widely existed in normal adult human tissues. The current study provided for the first time a comprehensive expres-sion of TMP21 in normal adult human tissues. It will benefit on helping in the design and interpretation of future studies focused on expounding the function of TMP21. can jelly freezeWeb230 MiTk ® P ® Product Catalog Copyright 2024 iTe ndustries nc All Rights Reserved WP Hangers EWP Hangers TMP / TMPH Adjustable Rafter-To-Plate Connectors The TMP ... can jelly go bad after openingWebOct 22, 2024 · In the present study, we investigated the role of TMP21 in autophagy activation in different cell types. TMP21, a member of the p24 protein family, plays a … can jennifer tilly singWebFeb 23, 2024 · Recent studies suggest that TMP21 is a selective modulator of γ-secretase and its dysregulation affects APP processing, leading to increased Aβ generation. However, the genetic association between Tmp21 and Alzheimer’s disease (AD) remains elusive. In this study, we identified that a novel single-nucleotide polymorphism (SNP) rs12435391 … can jellyfish move on their own